GIMS.dx is a platform to improve processes of any NGS-based molecular diagnostic: germline and somatic. This includes genetic diagnostics of rare hereditary diseases, cancer predispositions and sequencing analyses of tumor materials as well.
GIMS.dx harbours structured step by step decision-making and doumentation-workflows for variant classification, clinical interpretation and recommendation.
With GIMS.dx physicians and scientists in genetics and pathology can do their important work in a structured ecosystem that is the basis for better medical decisions.
By using GIMS, molecular and clinical teams work together in a digital genetic ecosystem. The aggregated knowledge and findings become transparently trusted and disseminated: the fair sharing of variant information, genetic knowledge and clinical observations is part of a continuous truth-finding process.
1. variant list (vcf) is uploaded with standard interfaces or manually
2. detected variants are listed and automatically connected with metadata from public sources
a) if a variant is already available in the system and trustfully classified, it can be processed automatically for generation of a report in clinical grade
b) to process formerly not classified variants the user is guided through the variant assessment and interpretation process step by step. Decision and argumentation processes can be document and versionised
c) where possible, the user can also draw variant information and existing assessments from the sharing network
3. Completed assessments can be reviewed and approved using customizable workflows
a) once assessments has reached a level of maturity, the customer can choose to share the knowledge within the network
4. Interpretations, diagnosis and recommendations are compiled in a clinical report available in multiple formats using content from the database amended with the user´s comments where applicable
5. Results can be
a) provided to physicians and patients as printed documents
b) incorporated into EHR systems or
c) distributed using customizable digital channels
Stepwise guidance through variant classification and interpretation process:
Structured documentation process with clear-cut workflows for review and approval processes: